Nitrazepam has long been associated with significant hepatic Conditions, just like other nitrobenzodiazepines. Nitrobenzodiazepines for example nitrazepam, nimetazepam, flunitrazepam, and clonazepam are more harmful for the liver than other benzodiazepines as They can be metabolically activated by CYP3A4 which may lead to cytotoxicity.Nitrazepam 10